Antiepileptic properties of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2 H -thiazolo[3,2 -a ]pyrimidin-3(7 H )-one derivatives
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چکیده
منابع مشابه
SELECTIVE CYCLIZATION OF 2-PROPARGYLTHIO-6-METHYL-PYRIMIDIN- 4(1 H)-ONE TO THIAZOLO [3,2-a] PYRIMIDIN 7-ONE
Selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1H)On e (2) to 3,5-dimethyl-7H-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . For elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). These compounds underwent isomerization to (3) and (4...
متن کاملCyclohexanespiro-2′-[2′,3′,6′,7′-tetrahydro-1′H-cyclopenta[d]pyrimidin]-4′(5′H)-one
The title compound, C(12)H(18)N(2)O, was synthesized by the reaction of cyclo-hexa-none and 2-amino-cyclo-pent-1-enecarbonitrile. In the mol-ecule of the title compound, the six-carbon ring displays a chair conformation, the six-membered 1,3-diaza ring and the cyclo-pentene ring both assume envelope conformations. Supra-molecular aggregation is achieved by N-H⋯O hydrogen bonds.
متن کاملselective cyclization of 2-propargylthio-6-methyl-pyrimidin- 4(1 h)-one to thiazolo [3,2-a] pyrimidin 7-one
selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1h)on e (2) to 3,5-dimethyl-7h-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . for elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). these compounds underwent isomerization to (3) and (4) r...
متن کاملSynthesis and structure-activity relationship study of 2-(substituted benzylidene)-7-(4-fluorophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-one derivatives as anticancer agents.
The synthesis and structure-activity relationship (SAR) study of a series of 2-(substituted benzylidene)-7-(4-fluorophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-one (4a-4j) derivatives as anticancer agents are described. This series of thiazolopyrimidines were synthesized by the reaction of 7-(4-fluoro phenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a] pyrimidin-3(7H)-one (3) with appropriat...
متن کاملN-(2-Bromo-4-methylphenyl)-2-(5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl)acetamide
The fused pyrazole and pyrimidine rings in the title compound, C22H19BrN4O, are almost coplanar, their planes being inclined to one another by 2.08 (13)°. The dihedral angles formed by the mean plane of the fused ring system and the phenyl and benzene rings are 16.21 (4) and 82.84 (4)°, respectively. An intra-molecular N-H⋯N hydrogen bond is observed. In the crystal, mol-ecules form inversion d...
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ژورنال
عنوان ژورنال: Journal of Saudi Chemical Society
سال: 2016
ISSN: 1319-6103
DOI: 10.1016/j.jscs.2012.07.018